Alpha-lipoic acid
Natural Standard evidence-based flashcard. Copyright © 2008 (www.naturalstandard.com). Commercial distribution prohibited. This flashcard is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions. 		Image
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.

Summary:
Alpha-lipoic acid (ALA) is most effective at lowering blood sugar levels if it is injected. However, it may also be effective when taken by mouth. Alpha-lipoic acid (ALA) has not been proven for any other health conditions and may not benefit healthy people.

Uses
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Grade*
Diabetes B
Nerve pain or damage B
Alcoholic liver damage C
Glaucoma C
Radiation exposure C
*Key to grades: A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).

Safety:
Avoid if allergic to Alpha-lipoic acid (ALA). In one study, pain and redness occurred around a needle site when ALA was injected through a vein. Avoid with thiamine deficiency or history of thyroid disease, alcoholism or stroke. Use caution with drugs that change blood sugar levels, thyroid hormones or increase bleeding risk. Avoid if pregnant or breastfeeding.

Possible side effects:
Bleeding, breathing problems, bruising, changes in blood sugar, changes in thyroid hormone, itching, liver weakness, nausea, numbness, skin rash, vomiting.

Possible Interactions:
Adriamycin, doxorubicin, drugs broken down by the liver, drugs that change blood sugar levels (like insulin), thiamine (B1), vitamin C, or herbs and supplements with similar effects.

Dosing:
Safe when following recommend dosages for up to two years.

Adults (18 years or older):
Blood sugar and treating diabetic nerve pain (neuropathy): 800-1800 milligrams has been taken by mouth daily, in divided doses.
Drug-induced cardiotoxicity: 100 milligrams per kilogram has been used.

Children (younger than 18 years):
Not enough scientific data available.
Natural Standard Monograph (www.naturalstandard.com)
Copyright © 2008 Natural Standard Inc. Commercial distribution or reproduction prohibited.
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.