American hellebore
Natural Standard evidence-based flashcard. Copyright © 2008 (www.naturalstandard.com). Commercial distribution prohibited. This flashcard is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions. 		Image
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.

Summary:
American hellebore is a plant native to the swampy areas and moist meadows of the eastern and western United States. Although American hellebore was formerly used as a tea or tincture, potentially toxic and irritating constituents preclude its modern day use by mouth. Native Americans used American hellebore as an antidote to madness, and the roots were mashed and applied to snakebites.

Uses
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Grade*
Cardiovascular and kidney dysfunction C
High blood pressure C
Pre-eclampsia/pregnancy-induced high blood pressure C
*Key to grades: A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).

Safety:
Avoid if allergic/hypersensitive to plants in the lily family (Liliaceae) or to American hellebore or any related species of Veratrum. Use cautiously with cardiovascular disease, cardiac dysfunction, arrhythmias, hemodynamic instability and compromised kidney function. Use cautiously in if taking drugs-excreted by the kidney, diuretics, asthma medications of blood pressure medications. Avoid if pregnant or breastfeeding.

Possible side effects:
Alterations in kidney function, arrhythmias, bradycardia (slow heart rate), depressed mental status, diarrhea, gastrointestinal problems, headache, hypotension, nausea, and vomiting.

Possible interactions:
Antiarrhythmics (heart medications), antihypertensives (used to lower blood pressure), beta-agonists, beta-blocker drugs, diuretics, drugs that are toxic or cleared by the kidneys, and herbs and supplements with similar effects.

Dosing:

Adults (18 years and older):
No safe dosage of American hellebore has been clinically established.

Children (younger than 18 years):
Not enough scientific data available.
Natural Standard Monograph (www.naturalstandard.com)
Copyright © 2008 Natural Standard Inc. Commercial distribution or reproduction prohibited.
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.