| Annatto Natural Standard evidence-based flashcard. Copyright © 2008 (www.naturalstandard.com). Commercial distribution prohibited. This flashcard is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions. |
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| While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy. | |
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Annatto is produced from the reddish pulp that surrounds the seed of the achiote (Bixa orellana L.). Today, annatto is commonly used as a coloring agent for pharmaceutical ointments and plasters and sometimes as a substitute for saffron. Annatto has also long been a staple in Latin American cooking and Caribbean cuisines as both a coloring agent and for flavoring. Annatto has traditionally been used for diabetes and snakebites. Although preliminary animal and laboratory evidence supports these uses, there is insufficient available evidence in humans to support the use of annatto for any indication. |
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No available studies qualify for inclusion in the grading table. |
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Avoid if allergic or hypersensitive to Bixa orellana (annatto, annatto seeds), its constituents, or any members of the Bixaceae family. Use cautiously with impaired kidney function. Use cautiously if taking mutagenic agents, diuretics (increase urination), antihypertensive (blood pressure-lowering) agents, and agents that are metabolized via CYP450. Avoid with diabetes. Avoid in medicinal amounts if pregnant or breastfeeding and in children. |
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Altered glycemic (blood sugar) and insulin levels, angioedema (swelling beneath the skin), diuretic effects (increased urination), eczema (skin disorder), hyperinsulinemia (increased insulin levels), hypotension (low blood pressure), increased effects of medications used to treat low blood pressure, urticaria (hives). |
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Aldose reductase inhibitors, analgesics (pain relievers), antibiotics, antidiabetic agents, antidiarrheals, antihypertensives (blood pressure-lowering agents), antineoplastic (anticancer) agents (cyclophosphamide), antioxidants, antivenins, CNS (central nervous system) depressants, cytochrome P450 metabolized agents, diuretics (promote urination), insulin preparations, nonsteroidal anti-inflammatory agents (NSAIDs), COX 2 inhibitors, oral drugs (taken by mouth), sedatives (cause drowsiness), and herbs and supplements with similar effects. |
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There are currently no high-quality trials investigating the safety and efficacy of any given doses. |
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Not enough scientific data available. |
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Natural Standard Monograph (www.naturalstandard.com)
Copyright © 2008 Natural Standard Inc. Commercial distribution or reproduction prohibited. |
| The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions. | |